Histology Guide

virtual histology laboratory

Chapter 8 - Hematopoiesis

Hematopoiesis is the formation of blood cell components. It occurs in the bone marrow of adults.

Bone Marrow Smear

MH 034a Bone Marrow Smear

(Wright's stain)

Blood cell development is shown using a single, high-resolution 60x scan from the zone of best morphology. This allows the morphology and staining characteristics of different cell types to be compared.

Erythropoiesis

Erythropoesis is the formation of red blood cells. Granules are never seen in the lineage of red blood cells.

MH 034bhr Red Blood Cell Development

(Wright's stain)

Granulopoiesis

Granulopoesis is the formation of white blood cells (leukocytes). Cells in the lineage of white blood cells contain azure granules (lysosomes) and in their later stages azure and specific granules. The specific granules are lightly stained in neutrophils, eosinophilic in eosinophils, and basophilic in basophils.

MH 034bhr Neutrophil Development

(Wright's stain)

MH 034bhr Eosinophil Development

(Wright's stain)

MH 034bhr Basophil Development

(Wright's stain)

Agranlocytes

Agranulocytes are white blood cells (leukocytes) with an absence of granules in their cytoplasm.

MH 034bhr Lymphocytes

(Wright's stain)

MH 034bhr Plasma Cell

(Wright's stain)

MH 034bhr Monocyte

(Wright's stain)

Thrombopoiesis

Thrombopoiesis is the formation of platelets. The largest cells found in bone marrow are megakaryocytes which give rise to pletelets.

MH 034a/MH 034bhr Megakaryocyte and Platelet Formation

(Wright's stain)

Review

This diagram allows the morphology and staining characteristics of different cell types to be compared.

MH 034bhr Bone Marrow Smear

(Wright's stain)

Quiz

Can you identify the different stages of blood cell development?

MH 034bhr Bone Marrow Smear

(Wright's stain)

This a different region from the slide used above. It can also be used to examine whether you can identify the stages of blood cell development.

MH 034bhr Bone Marrow Smear

(Wright's stain)

Other Examples

Viewing of these slides is not required. However, they demonstrate the variability seen between different preparations of bone marrow smears.

MH 034f Bone Marrow Smear (osteoclast)

(Wright's stain)

MH 034ahr Bone Marrow Smear

(Wright's stain)

MH 034dhr Bone Marrow Smear

(Wright's stain)

MH 034ehr Bone Marrow Smear

(Wright's stain)

MH 034fhr Bone Marrow Smear

(Wright's stain)