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CHAPTER 8 - HEMATOPOIESIS
Histology Guide
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MICROGRAPH

NAME
EM 347 Megakaryocyte
TISSUE
Bone Marrow
IMAGE SIZE
8,176 x 7,085 pixels
166 MB
FILE SIZES
57,493 KB (grayscale)
58,343 KB (color)
MAGNIFICATION
Unknown
PIXEL SIZE
4.892 nm
SOURCE
G. Adolph Ackerman
Department of Anatomy
Ohio State University
Columbus, Ohio

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EM 347 Megakaryocyte

Megakaryocyte

Transmission electron micrograph (TEM) of a megakaryocyte in bone marrow. Megakaryocytes are large polyploid cells that produce platelets. They grow by replicating its DNA without going through cytokinesis (endomitosis).

Most of the cytoplasm contains extensive invaginations of the plasma membrane forming an interconnected tubular system (platelet demarcation channels). These fragment into platelets

  • Nuclei (blue) / Nuclear Envelope (purple) – large nucleus with many lobes
  • Golgi Apparatus (yellow)
  • Mitochondria (red)
  • Platelets (purple) - in various stages of development
    • Often have dark cores
  • Cytoplasm (green)
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