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CHAPTER 10 - LYMPHOID SYSTEM
Histology Guide
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MICROGRAPH

NAME
EM 380 Spleen
TISSUE
Spleen
White Pulp
IMAGE SIZE
10,738 x 8,274 pixels
267 MB
FILE SIZES
56,419 KB (grayscale)
80,714 KB (color)
MAGNIFICATION
Unknown
PIXEL SIZE
5.418 nm
SOURCE
Ralph M. Steinman
Department of Immunology
The Rockefeller University
New York, NY

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EM 380 Spleen

Spleen

Transmission electron microscopy (TEM) of the white pulp in the spleen.

The white pulp of the spleen produces and stores lymphocytes (B-cells and T-cells), which are critical for adaptive immunity. It helps the body detect and respond to pathogens.

  • (green)
    • Small, rounded cells with minimal cytoplasm
    • Highly heterochromatic nuclei
  • Dendritic Cells (,; tan) - capture antigens and present them to lymphocytes
    • Irregularly shaped nuclei with a thin marginal layer of heterochromatin
    • Long branching cytoplasmic processes
    • Cytoplasm contains few organelles
  • (red) - line blood vessels
    • Crucial role in the passage of cells and substances between the bloodstream and surrounding immune cells
  • Reticular Fibers (,; yellow) - network of fibers composed of type III collagen that provides a framework for other cells
    • Wrapped by reticular cells

Courtesy of Ralph M. Steinman, Department of Immunology, The Rockefeller University, New York, NY.

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