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CHAPTER 7 - PERIPHERAL BLOOD
Histology Guide
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MICROGRAPH

NAME
EM 386 Eosinophil
TISSUE
Blood Smear
IMAGE SIZE
7,169 x 7,708 pixels
166 MB
FILE SIZES
19,493 KB (grayscale)
21,171 KB (color)
MAGNIFICATION
Unknown
PIXEL SIZE
2.307 nm
SOURCE
Stanley L. Erlandsen
Department of Genetics, Cell Biology and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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EM 386 Eosinophil

Eosinophil

Transmission electron microscopy (TEM) of an eosinophil in a blood smear.

Eosinophils are white blood cells that migrate from the bloodstream into tissues. They play a role in many inflammatory processes, including parasitic infections, allergic conditions, and asthma.

Eosinophils can be easily identified by their distinctive granules

  • (blue) / Nuclear Envelope (purple) - typically have a bilobed nucleus
  • (orange) - abundant large, specific granules (0.5 to 1.5 µm in diameter) with an ellipsoid shape and a linear, crystalline core
    • Crystalloid core is composed of major basic protein
    • Matrix contains eosinophil peroxidase, eosinophil cationic protein, along with cytokines, chemokines, and enzymes (such as RNase and DNase)
  • (yellow)
  • (red)
  • (cyan) - scattered fragments
  • (black) - a few smaller, round lysosomes
  • Cytoplasm (green)

Parts of red blood cells (red) and a white blood cell (tan) are observed around the eosinophil.

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