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CHAPTER 7 - PERIPHERAL BLOOD
Histology Guide
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MICROGRAPH

NAME
RD 120 Red Blood Cells
TISSUE
Human Blood
IMAGE SIZE
7,364 x 6,486 pixels
137 MB
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30,564 KB (grayscale)
30,667 KB (color)
MAGNIFICATION
1,600x
PIXEL SIZE
5.549 nm
SOURCE
Ronald W. Dudek
Brody School of Medicine
East Carolina University
Greenville, North Carolina

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RD 120 Red Blood Cells

Red Blood Cells

Transmission electron micrograph (TEM) of red blood cells (erythrocytes) in a large artery.

A red blood cell is a biconcave disc (i.e., dumbbell) about 7.8 µm in diameter.

  • Plasma Membrane - flexible network of cytoskeletal proteins bound to its interior
    • Allows deformation to pass through small diameter capillaries
  • Nucleus - absent in mature (human) red blood cells
  • Organelles - absent in mature red blood cells
    • Use anaerobic glycolysis as an energy source because of the absence of mitochondria
  • Cytoplasm - contains a high concentration of hemoglobin and a limited number of enzymes for cell maintenance
    • Uniform granular appearance of high electron density due to the iron atoms in hemoglobin

Reticulocytes are immature red blood cells without a nucleus but contain some ribosomes, mitochondria, and granules. Typically, 1 to 2% of circulating red blood cells.

Courtesy of Ronald W. Dudek, Brody School of Medicine, East Carolina University, Greenville, North Carolina.

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