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Eosinophils develop from the multipotential myeloid stem cell (CFU-GEMM) which differentiates into eosinophilic progenitor cells (CFU-Eo).
Eosinophilic myeloblasts are produced from progenitor cells (CFU-Eo) under the influence of cytokines. The eosinophil myeloblast matures into an eosinophilic promyelocyte. These cells cannot be distinguished from cells at the same stage in other granulocyte lineages.
Eosinophilic myelocyte is the first recognizable precursor of eosinophils.
Large cells (18 to 20 µm diameter)
Round, oval, or indented nucleus (50% of cell) with a coarser, granular pattern of chromatin
Cytoplasm is pale blue
Very eosinophilic, specific granules begin to accumulate
Mature eosinophils are released from bone marrow into the peripheral circulation. They circulate in the blood 8 to 16 hrs. Their tissue life span is only 2 to 5 days.
