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CHAPTER 11 - SKIN
Histology Guide
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MICROSCOPE SLIDE

SLIDE NAME
MH 091bhr Thick Skin
TISSUE
Thick Skin, Thumb
(human)
STAIN
Hematoxylin & Eosin
IMAGE SIZE
18,488 x 17,541 pixels
1.2 GB
FILE SIZE
62 MB
OBJECTIVE
60x
(oil immersion objective)
PIXEL SIZE
0.3171 µm
SOURCE
Department of Genetics, Cell Biology, and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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University of Minnesota
Department of Genetics, Cell Biology and Development
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MH 091bhr Thick Skin

Thick Skin

This image was obtained with a 60x oil immersion objective. The increased resolution is helpful in viewing thick skin.

Thick skin (>5 mm) covers the palms of the hand and soles of the feet. The outer keratin layer is substantially thicker than in other parts of the body.

  • - stratified squamous keratinized epithelium divided into five strata (or layers).
    • - single layer of germinal cells resting on the basement membrane which is attached to the dermis.
    • - keratinocytes attached to each other by desmosomes on spiny processes.
    • - keratinocytes with numerous basophilic granules in their cytoplasm.
    • Stratum Lucidum - highly refractive zone only seen in very thick skin (see MH 235 Thick Skin).
    • - thick layer of dead cells devoid of nuclei and organelles.
  • - dense irregular connective tissue that supports the epidermis.
    • - papillae that project into the dermis.
      • - increase adhesion between the epidermis and dermis.
      • - bring nutrients to the epidermis.
    • - dense irregular connective tissue.
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