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CHAPTER 11 - SKIN
Histology Guide
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MICROSCOPE SLIDE

SLIDE NAME
MHS 235 Thick Skin
TISSUE
Thick Skin
STAIN
Hematoxylin & Eosin
IMAGE SIZE
12,100 x 19,180 pixels
865 MB
FILE SIZE
367 MB
OBJECTIVE
40x
PIXEL SIZE
0.3171 µm
SOURCE
T. Clark Brelje and Robert L. Sorenson
Department of Genetics, Cell Biology, and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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Robert L. Sorenson, Ph.D.

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University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

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MHS 235 Thick Skin

Thick Skin

Thick skin (>5 mm) covers the palms of the hand and soles of the feet. The outer keratin layer is substantially thicker than in other parts of the body.

This specimen has a distinctive stratum lucidum.

  • - stratified squamous keratinized epithelium divided into five strata (or layers).
    • - single layer of germinal cells resting on the basement membrane which is attached to the dermis.
    • - keratinocytes attached to each other by desmosomes on spiny processes.
    • - keratinocytes with numerous basophilic granules in their cytoplasm.
    • - highly refractive zone only seen in very thick skin.
    • - thick layer of dead cells devoid of nuclei and organelles.
  • - dense irregular connective tissue that supports the epidermis.
    • Papillary Layer - papillae that project into the dermis.
      • - increase adhesion between the epidermis and dermis.
    • Reticular Layer - dense irregular connective.
      • - coiled tubular glands and ducts with simple or stratified cuboidal epithelium.
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