Pacinian corpuscles (or lamellar corpuscles) are nerve endings responsible for sensitivity to vibration and pressure. They occur in skin, mesentery, joints, and some abdominal organs (notably the pancreas).
This section of pancreas is stained with Masson's trichrome to show connective tissue (blue), nuclei (bright red) and cytoplasm (red/magenta).
Pacinian corpuscles (#1 and #2) are large oval or spherical structures of 20 to 60 concentric lamellae.
At its center (#1 and #2) is an unmyelinated axon of a sensory neuron and several lamellae of Schwann cells.
Most of the corpuscle is concentric lamellae separated by fluid. The flattened cells that form these are fibroblasts similar to those located in the endoneurium around peripheral nerves.
Deformation of the lamellae increases pressure on the axon causing the generation of nerve impulses.