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CHAPTER 5 - CARTILAGE AND BONE
Histology Guide
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MICROSCOPE SLIDE

SLIDE NAME
MH 020b Pig Snout Fetal
TISSUE
Pig Snout
(fetal)
STAIN
Hematoxylin & Eosin
FIXATIVE
10% Formaldehyde
IMAGE SIZE
34,920 x 15,866 pixels
2.1 GB
FILE SIZE
145 MB
OBJECTIVE
40x
PIXEL SIZE
0.3171 µm
SOURCE
Department of Genetics, Cell Biology, and Development
School of Medicine
University of Minnesota
Minneapolis, MN

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Robert L. Sorenson, Ph.D.

Professor Emeritus
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

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MH 020b Pig Snout Fetal

Chondrogenesis

occurs as two large, oval structures near the midline of this specimen. Cartilage development begins with the aggregation of mesenchymal cells that differentiate into chondroblasts. With the initiation of matrix production, the cells become surrounded by and are called .

Cartilage growth continues by two processes:

  • Appositional Growth - forms new cartilage on the surface of existing cartilage. The is a layer of dense irregular connective tissue that surrounds cartilage. It is divided into two layers:
    • - contains fibroblasts that produce the type I collagen on the outer surface of the perichondrium.
    • - contains fibroblast-like cells that differentiate into chondroblasts, initiate matrix production (type II collagen), and become immature chondrocytes. The new matrix increases cartilage mass.
  • Interstitial Growth - forms new cartilage within the existing cartilage. divide and the daughter cells move apart from each other. This is only possible when the surrounding matrix is distensible.

Unlike the basophilia of mature cartilage, developing cartilage is pale staining because sulfated glycosaminoglycans (GAGs) have not been added to the matrix.

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